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phenylacetate degradation (aerobic)

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
(3S)-3-hydroxyadipyl-CoA + NAD+ <=> H+ + 3-oxoadipyl-CoA + NADH 1.1.1.157 3-hydroxybutyryl-CoA dehydrogenase
1.1.1.35 3-hydroxyacyl-CoA dehydrogenase


phenylacetate + ATP + CoA <=> phenylacetyl-CoA + AMP + diphosphate 6.2.1.2 medium-chain acyl-CoA ligase
6.2.1.27 4-hydroxybenzoate---CoA ligase
6.2.1.30 phenylacetate---CoA ligase



3-oxo-5,6-dehydrosuberyl-CoA_semialdehyde + NADP+ + H2O <=> 3-oxo-5,6-dehydrosuberyl-CoA + NADPH + H+ 1.2.1.91 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase

succinyl-CoA + acetyl-CoA <=> 3-oxoadipyl-CoA + CoA 2.3.1.16 acetyl-CoA C-acyltransferase
2.3.1.174 3-oxoadipyl-CoA thiolase


2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA <=> 2-oxepin-2(3H)-ylideneacetyl-CoA 5.3.3.18 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase

2-oxepin-2(3H)-ylideneacetyl-CoA + H2O <=> 3-oxo-5,6-dehydrosuberyl-CoA_semialdehyde 3.3.2.12 oxepin-CoA hydrolase

phenylacetyl-CoA + O2 + NADPH + H+ <=> 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + NADP+ + H2O 1.14.13.149 phenylacetyl-CoA 1,2-epoxidase

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